Quantitative evaluation of genotoxicity data for risk assessment and regulatory decision-making: Time for a paradigm shift

Genotoxicity plays an important role in chemical safety assessment, as genetic alterations can lead to severe and irreversible health consequences. To date, the assessment of genotoxicity has mostly been limited to hazard identification, followed by rigorous risk mitigation measures if a substance i...

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Principais autores:	Benjamin Sachse, Sebastian Schmeisser, Jan van Benthem, Raffaella Corvi, Eugenia Dogliotti, Norman Ertych, Roland Frötschl, Ulrike Gündel, Kristin Herrmann, George Johnson, Carsten Kneuer, Jeannette König, Hans-Jörg Martus, Stefan Pfuhler, Stephanie Smith-Roe, Helga Stopper, Paul White, Tanja Schwerdtle, Andreas Hensel, Tewes Tralau
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2026-02-01
叢編:	Environment International
主題:	Genotoxicity Mutagenicity Quantitative approach Regulatory toxicology Risk assessment Symposium
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0160412026000280
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