Pharmacokinetic bioequivalence of the fixed-dose combination of pertuzumab and trastuzumab administered subcutaneously using a handheld syringe or an on-body delivery system

Abstract Purpose This randomized, open-label, two-arm, parallel-group, single dose, multi-center phase I study (ClinicalTrials.gov ID, NCT05275010) investigated the comparability of the pharmacokinetics of a new formulation combining pertuzumab (P) and trastuzumab (H) in one fixed-dose combination f...

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Autores principales:	Chris Wynne, Bei Wang, Rong Deng, Junyi Li, Daniel Eiger, Fabiola Bene Tchaleu, Sarah Heeson, Eleonora Restuccia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2025-06-01
Colección:	Journal of Cancer Research and Clinical Oncology
Materias:	Bioequivalence On-body delivery system Pharmacokinetics Pertuzumab Trastuzumab
Acceso en línea:	https://doi.org/10.1007/s00432-025-06228-4
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