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Pharmacokinetic bioequivalence of the fixed-dose combination of pertuzumab and trastuzumab administered subcutaneously using a handheld syringe or an on-body delivery system

Abstract Purpose This randomized, open-label, two-arm, parallel-group, single dose, multi-center phase I study (ClinicalTrials.gov ID, NCT05275010) investigated the comparability of the pharmacokinetics of a new formulation combining pertuzumab (P) and trastuzumab (H) in one fixed-dose combination f...

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Principais autores: Chris Wynne, Bei Wang, Rong Deng, Junyi Li, Daniel Eiger, Fabiola Bene Tchaleu, Sarah Heeson, Eleonora Restuccia
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-06-01
Serier:Journal of Cancer Research and Clinical Oncology
Fag:
Bioequivalence
On-body delivery system
Pharmacokinetics
Pertuzumab
Trastuzumab
Online adgang:https://doi.org/10.1007/s00432-025-06228-4
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