A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation

BackgroundChronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme of immune tolerance catalyzing the initial step of tryptophan degradation along the so-called l-kynurenine (l-kyn) pathway, that...

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主要な著者:	Massimo R. Mannarino, Vanessa Bianconi, Giulia Scalisi, Luca Franceschini, Giorgia Manni, Alessia Cucci, Francesco Bagaglia, Giulia Mencarelli, Francesco Giglioni, Doriana Ricciuti, Filippo Figorilli, Benedetta Pieroni, Elena Cosentini, Eleonora Padiglioni, Cecilia Colangelo, Dietmar Fuchs, Paolo Puccetti, Antonia Follenzi, Matteo Pirro, Marco Gargaro, Francesca Fallarino
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2023-04-01
シリーズ:	Frontiers in Immunology
主題:	EPC — endothelial progenitor cells kynurenine (KYN) IDO1 enzyme low-grade inflammation IL-6 (interleukin 6) hs-CRP (high sensitivity C-reactive protein)
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.964660/full
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