A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation

BackgroundChronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs). Indoleamine 2,3-dioxygenase 1 (IDO1), a key enzyme of immune tolerance catalyzing the initial step of tryptophan degradation along the so-called l-kynurenine (l-kyn) pathway, that...

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Bibliografiska uppgifter

Huvudupphov:	Massimo R. Mannarino, Vanessa Bianconi, Giulia Scalisi, Luca Franceschini, Giorgia Manni, Alessia Cucci, Francesco Bagaglia, Giulia Mencarelli, Francesco Giglioni, Doriana Ricciuti, Filippo Figorilli, Benedetta Pieroni, Elena Cosentini, Eleonora Padiglioni, Cecilia Colangelo, Dietmar Fuchs, Paolo Puccetti, Antonia Follenzi, Matteo Pirro, Marco Gargaro, Francesca Fallarino
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2023-04-01
Serie:	Frontiers in Immunology
Ämnen:	EPC — endothelial progenitor cells kynurenine (KYN) IDO1 enzyme low-grade inflammation IL-6 (interleukin 6) hs-CRP (high sensitivity C-reactive protein)
Länkar:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.964660/full
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