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4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating arthritis and joint pain can persist for months t...

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Furkejuvvon:
Váldodahkkit: Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: American Society for Microbiology 2024-06-01
Ráidu:mBio
Fáttát:
alphavirus
chikungunya virus
mayaro virus
antiviral
RNA replication
Liŋkkat:https://journals.asm.org/doi/10.1128/mbio.00420-24
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