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4′-Fluorouridine inhibits alphavirus replication and infection in vitro and in vivo

ABSTRACT Chikungunya virus (CHIKV) is an enveloped, positive-sense RNA virus that has re-emerged to cause millions of human infections worldwide. In humans, acute CHIKV infection causes fever and severe muscle and joint pain. Chronic and debilitating arthritis and joint pain can persist for months t...

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Principais autores: Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2024-06-01
coleção:mBio
Assuntos:
alphavirus
chikungunya virus
mayaro virus
antiviral
RNA replication
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.00420-24
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