Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma

Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and kill infected cells, yet their role in OAC is unknown. We aimed to elucidate the...

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Detalhes bibliográficos

Principais autores:	Ashanty M. Melo, Aisling M. O'Brien, James J. Phelan, Susan A. Kennedy, Nicole A. W. Wood, Natacha Veerapen, Gurdyal S. Besra, Niamh E. Clarke, Emma K. Foley, Akshaya Ravi, Finbar MacCarthy, Dermot O'Toole, Narayamasami Ravi, John V. Reynolds, Melissa J. Conroy, Andrew E. Hogan, Jacintha O'Sullivan, Margaret R. Dunne
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-07-01
coleção:	Frontiers in Immunology
Assuntos:	MAIT cells oesophageal adenocarcinoma Barrett's Oesophagus cancer immunology tumor microenvironment PD-1
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01580/full
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