Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48

Abstract Background Norvancomycin has been widely used in clinic to treat against MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (Methicillin-resistant Staphylococcus epidermidis) infections in China. Amycolatopsis orientalis NCPC 2-48, a high yield strain derived from A. orientalis CPC...

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Autori principali:	Xingxing Li, Cong Zhang, Ying Zhao, Xuan Lei, Zhibo Jiang, Xuexia Zhang, Zhihui Zheng, Shuyi Si, Lifei Wang, Bin Hong
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2021-02-01
Serie:	Microbial Cell Factories
Soggetti:	Norvancomycin Amycolatopsis orientalis Comparative transcriptomics Biosynthetic gene cluster Transcriptional regulation
Accesso online:	https://doi.org/10.1186/s12934-021-01521-6
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