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Comparative genomics and transcriptomics analyses provide insights into the high yield and regulatory mechanism of Norvancomycin biosynthesis in Amycolatopsis orientalis NCPC 2-48

Abstract Background Norvancomycin has been widely used in clinic to treat against MRSA (Methicillin-resistant Staphylococcus aureus) and MRSE (Methicillin-resistant Staphylococcus epidermidis) infections in China. Amycolatopsis orientalis NCPC 2-48, a high yield strain derived from A. orientalis CPC...

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Main Authors: Xingxing Li, Cong Zhang, Ying Zhao, Xuan Lei, Zhibo Jiang, Xuexia Zhang, Zhihui Zheng, Shuyi Si, Lifei Wang, Bin Hong
Format: Artigo
Language:Inglês
Published: BMC 2021-02-01
Series:Microbial Cell Factories
Subjects:
Norvancomycin
Amycolatopsis orientalis
Comparative transcriptomics
Biosynthetic gene cluster
Transcriptional regulation
Online Access:https://doi.org/10.1186/s12934-021-01521-6
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