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Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR. CLL-like stereotyped-IG rearrangements are present in normal B cells...

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Автори: Davide Bagnara, Monica Colombo, Daniele Reverberi, Serena Matis, Rosanna Massara, Niccolò Cardente, Gianluca Ubezio, Vanessa Agostini, Luca Agnelli, Antonino Neri, Martina Cardillo, Stefano Vergani, Fabio Ghiotto, Andrea Nicola Mazzarello, Fortunato Morabito, Giovanna Cutrona, Manlio Ferrarini, Franco Fais
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2022-06-01
Серія:Frontiers in Oncology
Предмети:
chronic lymphocytic leukemia (CLL)
immunoglobulin repertoire
B-cells
CD5
IGHV somatic mutations
Ig light chain
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fonc.2022.894419/full
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