LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
Pathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis. Activating mutations in LRRK2 kinase causes Parkinson’s diseas...
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| Principais autores: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Life Science Alliance LLC
2021-05-01
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| Serier: | Life Science Alliance |
| Online adgang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202101050 |
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