A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease, and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
eLife Sciences Publications Ltd
2022-09-01
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| Colección: | eLife |
| Materias: | |
| Acceso en línea: | https://elifesciences.org/articles/79771 |
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