Plasmodium falciparum HSP90 inhibitors show divergent resistance despite a shared ATP-binding site

Summary: Drug resistance poses a major challenge across therapeutic areas including malaria, yet factors governing resistance propensity remain poorly understood. We demonstrate that two HSP90 inhibitors targeting the identical ATP-binding site exhibit dramatically different resistance profiles in P...

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Principais autores:	Fu-Hsuan Ko, Amanda K. Lukens, Mariana Laureano de Souza, Alex Foy, Jason Hsiao, Tolla Ndiaye, John Okombo, Tomas Yeo, Heekuk Park, Anne-Catrin Uhlemann, Nonlawat Boonyalai, Krittikorn Kumpornsin, Gareth Girling, Charisse Pasaje, Luiz Godoy, Priyan Kapoor, Gregory L. Durst, Sabine Ottilie, Arnab Chatterjee, Jacquin Niles, Marcus Lee, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2026-07-01
סדרה:	Cell Reports
נושאים:	CP: microbiology
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2211124726007424
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