A Variant PfCRT Isoform Can Contribute to <italic toggle="yes">Plasmodium falciparum</italic> Resistance to the First-Line Partner Drug Piperaquine

ABSTRACT Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cam...

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Detalles Bibliográficos

Principais autores:	Satish K. Dhingra, Devasha Redhi, Jill M. Combrinck, Tomas Yeo, John Okombo, Philipp P. Henrich, Annie N. Cowell, Purva Gupta, Matthew L. Stegman, Jonathan M. Hoke, Roland A. Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J. Egan, David A. Fidock
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology 2017-07-01
Series:	mBio
Assuntos:	malaria PfCRT Plasmodium falciparum artemisinin-based combination therapies digestive vacuole genome editing
Acceso en liña:	https://journals.asm.org/doi/10.1128/mBio.00303-17
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