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Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis

Abstract The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS exposure in fully differentiated primary human bronchial...

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Principais autores: Marie Zöller, Michal Mastalerz, Elisabeth Dick, Juliane Merl-Pham, Elisabeth Hennen, Sai Rama Sridatta Prakki, Ashesh Chakraborty, Misako Nakayama, Markus Klotz, Hannah Marchi, Ronan LeGleut, Laurens J. De Sadeleer, Wim A. Wuyts, Bart M. Vanaudenaerde, Aicha Jeridi, Antje Prasse, Benedikt Jäger, Patricia Santofimia-Castaño, Mircea-Gabriel Stoleriu, Anne Hilgendorff, Stefanie M. Hauck, Ali Ö. Yildirim, Herbert Schiller, Claudia A. Staab-Weijnitz
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-05-01
Serier:Scientific Reports
Fag:
NUPR1
Cigarette smoke
Bronchial epithelium
IPF
ALI culture
In vitro
Online adgang:https://doi.org/10.1038/s41598-026-51510-1
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