Anti-DENV IgE correlates with dengue severity and triggers FcεRI-dependent basophil activation inhibited by Omalizumab

Abstract Severe dengue, marked by plasma leakage, is often linked to secondary heterotypic dengue virus (DENV) infection. While mast cells and basophils contribute to dengue pathogenesis, the role of anti-DENV IgE remains unclear. Here, we investigated whether anti-DENV IgE promotes FcεRI-dependent...

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Autori principali:	Wilawan Chan-in, Vimvara Vacharathit, Walairat Tancharoen, Thaneeya Duangchinda, Juthathip Mongkolsapaya, DENFREE Thailand, Ponpan Matangkasombut
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Scientific Reports
Soggetti:	IgE Dengue Basophil Mast cell Omalizumab
Accesso online:	https://doi.org/10.1038/s41598-026-43199-z
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