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Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases

Hyperphosphorylation of microtubule-associated protein tau is a major driver in the etiology of multiple neurodegenerative diseases, such as Alzheimer’s disease (AD) and other tauopathies. Intracellular accumulation of hyperphosphorylated tau (pTau) decreases microtubule stability, induces protein a...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Jingfen Su, Yue Xiao, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wang
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: KeAi Communications Co., Ltd. 2024-12-01
Sraith:Medicine Plus
Ábhair:
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2950347724000562
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