The Wnt/β-catenin-P2-HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy

Abstract Background The Wnt/β-catenin signaling pathway is a crucial regulator of colorectal cancer (CRC) development; however, its downstream targets and mechanistic contributions to tumorigenesis remain incompletely understood. Hepatocyte nuclear factor 4 alpha (HNF4α), a transcription factor prim...

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Detalhes bibliográficos

Principais autores:	Weiyu Bai, Rui Dong, Chenglu Lu, Lei Sang, Qinggang Hao, Yingru Zhang, Rongyuan Sun, Junling Shen, Wenjing Zhu, Yan Sun, Jianwei Sun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Journal of Translational Medicine
Assuntos:	Colorectal cancer P1/P2-HNF4α Wnt/β-catenin TCF7L1
Acesso em linha:	https://doi.org/10.1186/s12967-025-07133-7
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