The Wnt/β-catenin-P2-HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy
Abstract Background The Wnt/β-catenin signaling pathway is a crucial regulator of colorectal cancer (CRC) development; however, its downstream targets and mechanistic contributions to tumorigenesis remain incompletely understood. Hepatocyte nuclear factor 4 alpha (HNF4α), a transcription factor prim...
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| Principais autores: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2025-11-01
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| Serier: | Journal of Translational Medicine |
| Fag: | |
| Online adgang: | https://doi.org/10.1186/s12967-025-07133-7 |
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