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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological f...

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Автори: Tian Lu, Yong Li, Wenchao Lu, TWGM Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou, Christopher L. Antos, Cheng Luo
Формат: Artigo
Мова:Inglês
Опубліковано: Elsevier 2021-10-01
Серія:Acta Pharmaceutica Sinica B
Предмети:
Hippo pathway
TEAD3
Covalent inhibitor
Palmitoylation inhibitor.
Онлайн доступ:http://www.sciencedirect.com/science/article/pii/S2211383521001544
Теги: Додати тег
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