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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3

The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological f...

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Príomhchruthaitheoirí: Tian Lu, Yong Li, Wenchao Lu, TWGM Spitters, Xueyu Fang, Jun Wang, Simian Cai, Jing Gao, Yanting Zhou, Zhe Duan, Huan Xiong, Liping Liu, Qi Li, Hualiang Jiang, Kaixian Chen, Hu Zhou, Hua Lin, Huijin Feng, Bing Zhou, Christopher L. Antos, Cheng Luo
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2021-10-01
Sraith:Acta Pharmaceutica Sinica B
Ábhair:
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S2211383521001544
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