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DNA secondary structure is influenced by genetic variation and alters susceptibility to <it>de novo </it>translocation

<p>Abstract</p> <p><b>Background</b></p> <p>Cumulative evidence suggests that DNA secondary structures impact DNA replication, transcription and genomic rearrangements. One of the best studied examples is the recurrent constitutional t(11;22) in humans that is mediated by potentially cruciform-formi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Tsutsumi Makiko, Yamada Kouji, Ohye Tamae, Kogo Hiroshi, Tong Maoqing, Inagaki Hidehito, Kato Takema, Emanuel Beverly S, Kurahashi Hiroki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2011-09-01
Schriftenreihe:Molecular Cytogenetics
Schlagworte:
Polymorphism
Palindrome
Secondary structure
Hairpin structure
Cruciform structure
Breakpoint
Translocation
Online-Zugang:http://www.molecularcytogenetics.org/content/4/1/18
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