mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...

Fuld beskrivelse

Bibliografiske detaljer

Principais autores:	Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 2023-01-01
Serier:	The Journal of Clinical Investigation
Fag:	Immunology Infectious disease
Online adgang:	https://doi.org/10.1172/JCI160025
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!