mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection

T cell exhaustion is a state of T cell dysfunction associated with expression of programmed death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells that provide differentiated TIM3+ cells, a part of which possesses effector-like properties. PD-1–targeted therapies en...

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Главные авторы:	Satomi Ando, Charles M. Perkins, Yamato Sajiki, Chase Chastain, Rajesh M. Valanparambil, Andreas Wieland, William H. Hudson, Masao Hashimoto, Suresh S. Ramalingam, Gordon J. Freeman, Rafi Ahmed, Koichi Araki
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Clinical Investigation 2023-01-01
Серии:	The Journal of Clinical Investigation
Предметы:	Immunology Infectious disease
Online-ссылка:	https://doi.org/10.1172/JCI160025
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