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Targeting Chitinase 1 and Chitinase 3-Like 1 as Novel Therapeutic Strategy of Pulmonary Fibrosis

Chitinase 1 (CHIT1) and chitinase 3-like-1 (CHI3L1), two representative members of 18-Glycosyl hydrolases family, are significantly implicated in the pathogenesis of various human diseases characterized by inflammation and remodeling. Notably, dysregulated expression of CHIT1 and CHI3L1 was noted in...

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Principais autores: Suh-Young Lee, Chang-Min Lee, Bing Ma, Suchitra Kamle, Jack A. Elias, Yang Zhou, Chun Geun Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-03-01
coleção:Frontiers in Pharmacology
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.826471/full
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