Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Abstract Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and serum...

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Hlavní autoři:	Chensi Liang, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Zhenlei Chen, Dan Can, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-03-01
Edice:	Advanced Science
Témata:	alzheimer's disease BACE1 glycosylation mannose β‐amyloid
On-line přístup:	https://doi.org/10.1002/advs.202409105
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