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Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Abstract Hyperglycemia accelerates Alzheimer's disease (AD) progression, yet the role of monosaccharides remains unclear. Here, it is demonstrated that mannose, a hexose, closely correlates with the pathological characteristics of AD, as confirmed by measuring mannose levels in the brains and serum...

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Autors principals: Chensi Liang, Ziqi Yuan, Shangchen Yang, Yufei Zhu, Zhenlei Chen, Dan Can, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang
Format: Artigo
Idioma:Inglês
Publicat: Wiley 2025-03-01
Col·lecció:Advanced Science
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Accés en línia:https://doi.org/10.1002/advs.202409105
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