Case Report: A Multi-Peptide Vaccine Targeting Individual Somatic Mutations Induces Tumor Infiltration of Neoantigen-Specific T Cells in a Patient with Metastatic Colorectal Cancer

Background/Objectives: Fully personalized peptide vaccines targeting tumor-specific mutations are a promising treatment option for patients in an adjuvant but also advanced/metastatic disease situation in addition to non-personalized standard therapies. Here, we report a patient’s case with advanced...

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Главные авторы:	Armin Rabsteyn, Henning Zelba, Borong Shao, Lisa Oenning, Christina Kyzirakos, Simone Kayser, Tabea Riedlinger, Johannes Harter, Magdalena Feldhahn, Dirk Hadaschik, Florian Battke, Veit Scheble, Alfred Königsrainer, Saskia Biskup
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2025-09-01
Серии:	Vaccines
Предметы:	personalized peptide vaccination metastatic colorectal cancer tumor-infiltrating lymphocytes neoantigens TCRβ sequencing
Online-ссылка:	https://www.mdpi.com/2076-393X/13/9/960
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