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Naturally-occurring DNA fragment termini correlate with methylation at CpG sites in hair and blood plasma cell-free DNA

Abstract Background CpG methylation is an important epigenetic regulator in growth, development, and disease and a biomarker of age. It was recently shown that CpG methylation influences nuclease activity in the natural process that generates blood plasma cell-free DNA fragments. This results in a c...

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Principais autores: Samuel Sacco, Joshua D. Kapp, Remy Nguyen, Isha S. Rao, Richard E. Green
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-02-01
coleção:BMC Genomics
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Acesso em linha:https://doi.org/10.1186/s12864-025-12459-z
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