Automated multiconformer model building for X-ray crystallography and cryo-EM

In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce density maps that are ensemble averages, reflecting mole...

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Detalles Bibliográficos

Principais autores:	Stephanie A Wankowicz, Ashraya Ravikumar, Shivani Sharma, Blake Riley, Akshay Raju, Daniel W Hogan, Jessica Flowers, Henry van den Bedem, Daniel A Keedy, James S Fraser
Formato:	Artigo
Idioma:	Inglês
Publicado:	eLife Sciences Publications Ltd 2024-06-01
Series:	eLife
Assuntos:	structural biology conformational heterogeneity cryo-EM protein dynamics X-ray crystallography
Acceso en liña:	https://elifesciences.org/articles/90606
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