Plasma concentration and efficacy of tolvaptan in cirrhotic patients with refractory ascites
To investigate the relationship between the exposure and efficacy of tolvaptan, we measured pharmacokinetics of total drug at 7 days after repeated doses of 3.75 mg/day tolvaptan in 16 patients with hepatic edema. Nine patients (56.3%) were responders, which were defined as those with body weight re...
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| Principais autores: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2019-04-01
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| Serier: | Journal of Pharmacological Sciences |
| Online adgang: | http://www.sciencedirect.com/science/article/pii/S1347861319300295 |
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