Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans
The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2016-01-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/ncomms10388 |
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