Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans

The molecular mechanism of axon regeneration after injury is poorly understood. Here the authors show that in C. elegans, the HIF-1 transcription factor induces ectopic synthesis of serotonin in severed ‘non-serotonergic’ neurons and that serotonin activates downstream signaling pathways leading to...

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Autors principals:	Tanimul Alam, Hiroki Maruyama, Chun Li, Strahil Iv. Pastuhov, Paola Nix, Michael Bastiani, Naoki Hisamoto, Kunihiro Matsumoto
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2016-01-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/ncomms10388
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