Bufalin Suppresses Colorectal Cancer Liver Metastasis by Inhibiting De Novo Fatty Acid Synthesis via the PI3K/AKT-Mediated SREBP1/FASN Pathway

Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with liver metastasis being the leading cause of mortality. De novo fatty acid synthesis plays a critical role in CRC progression and metastasis. Bufalin, a cardiotonic steroid isolated from toad skin, has demonstrated an...

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Autores principales:	Wenwen Pang, Xiang Li, Suying Yan, Junshi Zhang, Ping Wu, Haiyang Yu, Bowei Zhang, Chunze Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-09-01
Colección:	Molecules
Materias:	bufalin colorectal cancer liver metastasis de novo fatty acid synthesis PI3K/AKT-mediated SREBP1/FASN pathway
Acceso en línea:	https://www.mdpi.com/1420-3049/30/17/3634
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