Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), whose pathogenesis involves complex multi-organ crosstalk and the remodeling of the hepatic immune microenvironment, constitutes a major global health challenge. The latest research indicates that the dysregulation of the AMP...

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Detalhes bibliográficos

Principais autores:	Qiqi Zhao, Shengwen Lu, Yu Guan, Zhiwen Sun, Shi Qiu, Aihua Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-01-01
coleção:	Lipids in Health and Disease
Assuntos:	MASLD AMPK- SREBP1- FASN axis Microenvironment Metabolic-immune cycle Lipotoxicity.
Acesso em linha:	https://doi.org/10.1186/s12944-026-02867-9
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