New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.

Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replication. Here we show that CAG/CTG tracts are stabilize...

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Библиографические подробности

Главные авторы:	Lionel Gellon, David F Razidlo, Olive Gleeson, Lauren Verra, Danae Schulz, Robert S Lahue, Catherine H Freudenreich
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2011-02-01
Серии:	PLoS Genetics
Online-ссылка:	http://europepmc.org/articles/PMC3037408?pdf=render
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