Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

A long-running debate concerns whether dopamine or noradrenaline deficiency drives response disinhibition in Parkinson’s disease (PD). This study aimed to investigate whether damage to the locus coeruleus (LC) or substantia nigra (SN) might impact inhibitory functions of the fronto-subthalamic hyper...

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Auteurs principaux:	Biman Xu, Tingting He, Yuan Lu, Jia Jia, Barbara J. Sahakian, Trevor W. Robbins, Lirong Jin, Zheng Ye
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-01-01
Collection:	NeuroImage: Clinical
Sujets:	Locus coeruleus Fronto-subthalamic hyperdirect pathway Response inhibition Parkinson's disease Neuromelanin-sensitive MRI fMRI
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2213158222003412
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