Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Abstract Background Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the main driving force underlying immunosuppression in se...

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Opis bibliograficzny

Główni autorzy:	Avi Gillis, Michael Beil, Karin Halevi-Tobias, Peter Vernon van Heerden, Sigal Sviri, Zvia Agur
Format:	Artigo
Język:	Inglês
Wydane:	SpringerOpen 2019-06-01
Seria:	Intensive Care Medicine Experimental
Hasła przedmiotowe:	Simulations Dynamic model T lymphocyte exhaustion Immunosuppression Checkpoint blockers Hyper-inflammation
Dostęp online:	http://link.springer.com/article/10.1186/s40635-019-0260-3
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