Extracellular vesicle-associated PD-L1 induces CD4+ T cell dysfunction and contributes to immunosuppression in sepsis
Abstract Background The upregulation of PD-1 on T lymphocytes is one of the key mechanisms driving sepsis-induced immunosuppression. Nevertheless although it is known that PD-L1 on antigen-presenting cells acts as a ligand for PD-1 on T lymphocytes, it remains to be determined whether extracellular...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BMC
2026-02-01
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| Seria: | Cell Communication and Signaling |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1186/s12964-026-02724-3 |
| Etykiety: |
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