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Development and evaluation of vaccination strategies for addressing the continuous evolution SARS-CoV-2 based on recombinant trimeric protein technology: Potential for cross-neutralizing activity and broad coronavirus response

Given the significant decline in vaccine efficacy against Omicron, the development of novel vaccines with specific or broad-spectrum effectiveness is paramount. In this study, we formulated four monovalent vaccines based on recombinant spike trimer proteins, along with three bivalent vaccines, and f...

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Principais autores: Peng Du, Ning Li, Shengjun Tang, Zhongcheng Zhou, Zhihai Liu, Taorui Wang, Jiahui Li, Simiao Zeng, Juan Chen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-07-01
Serier:Heliyon
Fag:
SARS-CoV-2
Vaccination strategies
Immune evasion
Cross-neutralizing activity
Pan-coronavirus vaccine
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844024105233
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