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The mechanosensitive Piezo1 channel is required for bone formation

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is...

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Autori principali: Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2019-07-01
Serie:eLife
Soggetti:
Piezo1
mechanosensitive ion channel
mechanotransduction
bone formation
unloading
osteoblast
Accesso online:https://elifesciences.org/articles/47454
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