Torsion is a dynamic regulator of DNA replication stalling and reactivation

Abstract DNA’s helical structure necessitates replisome rotation relative to DNA during replication, creating inevitable topological challenges. How replication generates and overcomes torsional stress remains unclear. Here, we developed a high-resolution, label-free, real-time assay to track DNA ro...

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Autors principals:	Xiaomeng Jia, Xiang Gao, Shuming Zhang, James T. Inman, Yifeng Hong, Anupam Singh, Fahad Rashid, James M. Berger, Smita S. Patel, Michelle D. Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-025-65567-5
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