Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene

Multiple myeloma (MM) is the second most common hematologic malignancy, which is characterized by clonal proliferation of neoplastic plasma cells in the bone marrow. This microenvironment is characterized by low oxygen levels (1–6% O₂), known as hypoxia. For MM cells, hypoxia is a physiol...

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Auteurs principaux:	Ada-Sophia Clees, Verena Stolp, Björn Häupl, Dominik C. Fuhrmann, Frank Wempe, Marcel Seibert, Sarah Weber, Antje Banning, Ritva Tikkanen, Richard Williams, Bernhard Brüne, Hubert Serve, Frank Schnütgen, Ivana von Metzler, Nina Kurrle
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2022-01-01
Collection:	Cells
Sujets:	multiple myeloma chronic hypoxia asparaginyl endopepdidase (AEP) legumain glycolysis
Accès en ligne:	https://www.mdpi.com/2073-4409/11/2/292
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