Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well characterized. However, the specific mechanisms that AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to revea...

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Autors principals:	Mikayla Hoad, Emily M. Cross, Camilla M. Donnelly, Subir Sarker, Justin A. Roby, Jade K. Forwood
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-01-01
Col·lecció:	Viruses
Matèries:	Adeno-associated virus importin alpha nuclear localization binding interface structure
Accés en línia:	https://www.mdpi.com/1999-4915/15/2/315
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