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Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Adeno-associated viruses (AAV) are important vectors for gene therapy, and accordingly, many aspects of their cell transduction pathway have been well characterized. However, the specific mechanisms that AAV virions use to enter the host nucleus remain largely unresolved. We therefore aimed to revea...

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Uloženo v:
Hlavní autoři: Mikayla Hoad, Emily M. Cross, Camilla M. Donnelly, Subir Sarker, Justin A. Roby, Jade K. Forwood
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2023-01-01
Edice:Viruses
Témata:
Adeno-associated virus
importin alpha
nuclear localization
binding interface
structure
On-line přístup:https://www.mdpi.com/1999-4915/15/2/315
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