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Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression

Abstract The role of peridroplet mitochondria (PDM) in diseased liver, such as during the progression of metabolic dysfunction-associated steatohepatitis (MASH), remains unknown. We isolated hepatic cytoplasmic mitochondria (CM) and PDM from a mouse model of diet-induced MASLD/MASH to characterize t...

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Auteurs principaux: Noble Kumar Talari, Ushodaya Mattam, Afra P. Rahman, Brook K. Hemmelgarn, Michael A. Wyder, Pamela B. Sylvestre, Kenneth D. Greis, Karthickeyan Chella Krishnan
Format: Artigo
Langue:Inglês
Publié: Nature Portfolio 2025-02-01
Collection:Communications Biology
Accès en ligne:https://doi.org/10.1038/s42003-025-07713-9
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