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Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance

Abstract Background No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite drug discovery. Methods Six ESCC cell lines and 7 out of 25 PDX models de...

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Principais autores: Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao, Lin Shen
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-08-01
Serier:Journal of Hematology & Oncology
Fag:
ESCC
Mouse avatar
Afatinib
Src family kinases
Acquired resistance
Online adgang:http://link.springer.com/article/10.1186/s13045-018-0651-z
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