Mouse avatar models of esophageal squamous cell carcinoma proved the potential for EGFR-TKI afatinib and uncovered Src family kinases involved in acquired resistance

Abstract Background No approved targeted agents are available for esophageal squamous cell carcinoma (ESCC). Informative genomic analysis and mouse patient-derived xenografts (PDX) also called mouse avatar can greatly expedite drug discovery. Methods Six ESCC cell lines and 7 out of 25 PDX models de...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Zhentao Liu, Zuhua Chen, Jingyuan Wang, Mengqi Zhang, Zhongwu Li, Shubin Wang, Bin Dong, Cheng Zhang, Jing Gao, Lin Shen
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2018-08-01
Σειρά:	Journal of Hematology & Oncology
Θέματα:	ESCC Mouse avatar Afatinib Src family kinases Acquired resistance
Διαθέσιμο Online:	http://link.springer.com/article/10.1186/s13045-018-0651-z
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