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Novel CD123 polyaptamer hydrogel edited by Cas9/sgRNA for AML-targeted therapy

CD123 targeting molecules have been widely applied in acute myelocytic leukemia (AML) therapeutics. Although antibodies have been more widely used as targeting molecules, aptamer have unique advantages for CD123 targeting therapy. In this study, we constructed an aptamer hydrogel termed as SSFH whic...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Haibin Wu, Liyu Zhang, Zeen Zhu, Chenxi Ding, Shengquan Chen, Ruiping Liu, Huafeng Fan, Yang Chen, Hui Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2021-01-01
Schriftenreihe:Drug Delivery
Schlagworte:
cd123 aptamer
cas9/sgrna
controlled release
aml
polyaptamer hydrogel
Online-Zugang:http://dx.doi.org/10.1080/10717544.2021.1934191
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